abstract：:The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(...

journal_title：Cell biochemistry and function

authors： Coskun ZM,Bolkent S

更新日期：2014-10-01 00:00:00

abstract：:Several studies have highlighted the potential of leucine supplementation for the treatment of metabolic diseases including type 2 diabetes and obesity. Caloric restriction is a common approach to improve the health in diabetic and obese subjects. However, very few studies assessed the effects of leucine supplementati...

journal_title：Cell biochemistry and function

authors： Pedroso JA,Nishimura LS,de Matos-Neto EM,Donato J Jr,Tirapegui J

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effect of artemisinin on the proliferation and apoptosis of rat vascular smooth muscle cells (VSMCs). METHOD:Primary rat VSMCs were treated with various doses of artemisinin. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro...

journal_title：Cell biochemistry and function

authors： Wang HY,Huang RP,Han P,Xue DB,Li HB,Liu B,Shan P,Wang QS,Li KS,Li HL

更新日期：2014-03-01 00:00:00

abstract：:Sprouty1 protein belongs to a family of receptor tyrosine kinase-mediated signaling inhibitors, whose members are usually regulated by growth factors to form a negative feedback loop. Correspondingly fluctuations of Sprouty1 mRNA in response to single growth factors have been observed. In this report, we investigate S...

journal_title：Cell biochemistry and function

authors： Kral RM,Mayer CE,Vanas V,Gsur A,Sutterlüty-Fall H

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to investigate the protective effect of ferulic acid at different doses (50 mg kg(-1) alternative day and 50 mg kg(-1) daily) on the streptozotocin (STZ)-induced post-diabetes rat testicular damage. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). Rats treated wit...

journal_title：Cell biochemistry and function

authors： Roy S,Metya SK,Rahaman N,Sannigrahi S,Ahmed F

更新日期：2014-01-01 00:00:00

abstract：:Mast cells are widely distributed in the body and affect their surrounding environment through degranulation and secretion of cytokines. Conversely, mast cells are influenced by environmental stimuli such as cyclical mechanical stretch (CMS), such as that induced by heartbeat and respiration. Peripherally distributed ...

journal_title：Cell biochemistry and function

authors： Komiyama H,Miyake K,Asai K,Mizuno K,Shimada T

更新日期：2014-01-01 00:00:00

abstract：:Gout is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. In the present study, we aimed to investigate the anti-inflammatory effect of trikatu, a herbal compound in monosodium urate crystal-induced inflammation in rats, an experimental model f...

journal_title：Cell biochemistry and function

authors： Murunikkara V,Rasool M

更新日期：2014-01-01 00:00:00

abstract：:Liver-directed gene therapy has become a promising treatment for many liver diseases. In this study, we constructed a multi-functional targeting molecule, which maintains targeting, endosome-escaping, and DNA-binding abilities for gene delivery. Two single oligonucleotide chains of Melittin (M) were synthesized. The f...

journal_title：Cell biochemistry and function

authors： Wang W,Luo J,Xu L,Zeng J,Cao L,Dong J,Cai S

更新日期：2013-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties ...

journal_title：Cell biochemistry and function

authors： Adesanoye OA,Molehin OR,Delima AA,Adefegha AS,Farombi EO

更新日期：2013-10-01 00:00:00

abstract：:The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulati...

journal_title：Cell biochemistry and function

authors： Yang Y,Wolfram J,Boom K,Fang X,Shen H,Ferrari M

更新日期：2013-07-01 00:00:00

abstract：:Recent studies have demonstrated that germ-like cells could be differentiated from human umbilical cord mesenchymal stem cells (hUC-MSCs) in vitro. Whether the sexuality of hUC-MSCs affects the formation efficiency of germ-like cells derived from hUC-MSCs is still unclear. To clearly test the formation efficiency of o...

journal_title：Cell biochemistry and function

authors： Qiu P,Bai Y,Pan S,Li W,Liu W,Hua J

更新日期：2013-07-01 00:00:00

abstract：:Voltage-gated Ca(2+) channels regulate cardiac automaticity, rhythmicity and excitation-contraction coupling. Whereas L-type (Cav 1·2, Cav 1·3) and T-type (Cav 3·1, Cav 3·2) channels are widely accepted for their functional relevance in the heart, the role of Cav 2·3 Ca(2+) channels expressing R-type currents remains ...

journal_title：Cell biochemistry and function

authors： Galetin T,Tevoufouet EE,Sandmeyer J,Matthes J,Nguemo F,Hescheler J,Weiergräber M,Schneider T

更新日期：2013-07-01 00:00:00

abstract：:Deficiency in neutrophils (neutropenia) caused by mutations in neutrophil elastase (NE, ELA2) has been extensively investigated. Monocytes and neutrophils are derived from a common myeloid progenitor; therefore, ELA2 mutations can also influence monocyte development. These effects have not been well described. In this...

journal_title：Cell biochemistry and function

authors： Lee HH,Sung MH

更新日期：2013-06-01 00:00:00

abstract：:This study was designed to investigate the role of HO-1 induction in prevention of thioacetamide (TAA)-induced oxidative stress, inflammation and liver damage. The changes in hepatic dimethylarginine dimethylaminohydrolase (DDAH) activity as well as plasma arginine and asymmetric dimethylarginine (ADMA) levels were al...

journal_title：Cell biochemistry and function

authors： Develi-Is S,Bekpinar S,Kalaz EB,Evran B,Unlucerci Y,Gulluoglu M,Uysal M

更新日期：2013-03-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The in...

journal_title：Cell biochemistry and function

authors： Sharma U,Singh SK,Rajendra P

更新日期：2012-12-01 00:00:00

abstract：:CYR61 is one of the six proteins of the CCN family of proteins known to play diverse roles in angiogenesis, cellular proliferation, survival, migration and wound healing. However, the specific function of CYR61 in cancer is unclear, and the literature remains controversial. We used quantitative real-time PCR to establ...

journal_title：Cell biochemistry and function

authors： Jandova J,Beyer TE,Meuillet EJ,Watts GS

更新日期：2012-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells traditionally derived from bone marrow (BM). They have been demonstrated to be widely applied in tissue regeneration and cellular therapy. As an alternative to BM, an umbilical cord (UC) is considered as a potential source of MSCs. Here, we showed that human UC-MSCs ...

journal_title：Cell biochemistry and function

authors： Zhang H,Zhang B,Tao Y,Cheng M,Hu J,Xu M,Chen H

更新日期：2012-12-01 00:00:00

abstract：:We constructed the significant low-expression P-glycoprotein (ABCB1) inhibited transport and signal network in chimpanzee compared with high-expression (fold change ≥2) the human left cerebrum in GEO data set, by using integration of gene regulatory activated and inhibited network inference method with gene ontology (...

journal_title：Cell biochemistry and function

authors： Lin H,Wang L,Jiang M,Huang J,Qi L

更新日期：2012-10-01 00:00:00

abstract：:Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis...

journal_title：Cell biochemistry and function

authors： Farooqi AA,Naqi A,Qureshi MZ,Rana A,Khan A,Riaz AM,Afzal SM,Rasheed N,Bhatti S

更新日期：2012-10-01 00:00:00

abstract：:The protective effects of carnosine as a natural dipeptide were investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide. Mice were injected with solutions of carnosine at three different doses (10, 50 and 100 mg kg(-1) bw) for five consecutive days. On the fifth day of treatment, mice ...

journal_title：Cell biochemistry and function

authors： Naghshvar F,Abianeh SM,Ahmadashrafi S,Hosseinimehr SJ

更新日期：2012-10-01 00:00:00

abstract：:The use of Nigerian bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders, burns, foot ulcers and reproductive capacity is a common practice in the southern part of Nigeria. Towards understanding the mechanism and the reversibility of hepatotoxicity induced by BLCO, adult male Wistar rats were or...

journal_title：Cell biochemistry and function

authors： Adedara IA,Farombi EO

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Hydrogen peroxide (H(2)O(2)) is a potent reactive oxygen species that causes cardiomyocytes injury. As an important cytokine, interleukin 6 (IL-6) has cardioprotective effects as it plays an essential role in the late phase of preconditioning. Our work is to investigate if IL-6 preconditioning has protective ...

journal_title：Cell biochemistry and function

authors： Jia Y,Zhou F,Deng P,Fan Q,Li C,Liu Y,Fu X,Zhou Y,Xu X,Sun X

更新日期：2012-07-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) converts tryptophan to l-kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, to investigate the effects of IDO in carbon tetrachloride (CCl(4) )-induced hepatitis model, the levels of IDO enzymic activities in the...

journal_title：Cell biochemistry and function

authors： Li D,Cai H,Hou M,Fu D,Ma Y,Luo Q,Yuan X,Lv M,Zhang X,Cong X,Lv Z

更新日期：2012-06-01 00:00:00

abstract：:Organochalcogens are extensively produced and employed by industry and agriculture, and the risk of occupational and environmental toxicity to them has been poorly understood. Here, we investigated the acute effect of a new organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on biochemical and hematologic...

journal_title：Cell biochemistry and function

authors： dos Santos Lacerda D,de Oliveira Castro V,Mascarenhas M,Guerra RB,Dani C,Coitinho A,Gomez R,Funchal C

更新日期：2012-06-01 00:00:00

abstract：:Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signalling pathways including cervical cancer. However, the underlying mechanisms are still not well elucidated. Here, we assessed the effect of silibinin...

journal_title：Cell biochemistry and function

authors： Zhang Y,Ge Y,Chen Y,Li Q,Chen J,Dong Y,Shi W

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present studies was to determine whether the mechanism of biological action of garlic-derived sulfur compounds in human hepatoma (HepG2) cells can be dependent on the presence of labile sulfane sulfur in their molecules. We investigated the effect of allyl sulfides from garlic: monosulfide, disulfide an...

journal_title：Cell biochemistry and function

authors： Iciek M,Kwiecień I,Chwatko G,Sokołowska-Jeżewicz M,Kowalczyk-Pachel D,Rokita H

更新日期：2012-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an endothelium-specific mitogen and a promising inducer of angiogenesis and lymphangiogenesis. The VEGF receptors on endothelial cell membrane include the tyrosine kinases VEGFR-1 (Flt-1), VEGFR-2 (Flk-1/KDR) and VEGFR-3 (Flt-4). KDR is a major mediator of mitogenic, angiog...

journal_title：Cell biochemistry and function

authors： Ge X,Zhao L,He L,Chen W,Li X

更新日期：2012-03-01 00:00:00

abstract：:Prostate cancer metastasis is often associated with poor prognosis. The molecular coupling of the adaptor protein Crk to the docking protein p130(Cas) serves as a switch that regulates cell migration in several invasive cancer cells and Ack appears to act upstream of CrkII to modulate the cell motility. However, the p...

journal_title：Cell biochemistry and function

authors： Dai Y,Qi L,Zhang X,Li Y,Chen M,Zu X

更新日期：2011-12-01 00:00:00

abstract：:The vascular endothelium plays a key role in arterial wall homeostasis by preventing atherosclerotic plaque formation. A primary causal factor of endothelial dysfunction is the reactive oxygen species. Aerobic exercise is ascribed as an important adjuvant therapy in endothelium-dependent cardiovascular disease. Howeve...

journal_title：Cell biochemistry and function

authors： Schaun MI,Dipp T,Rossato Jda S,Wilhelm EN,Pinto R,Rech A,Plentz RD,Homem de Bittencourt PI,Reischak-Oliveira A

更新日期：2011-10-01 00:00:00

abstract：:The aim of the present work was to investigate the mechanisms of oxidative damage of the liver mitochondria under diabetes and intoxication in rats as well as to evaluate the possibility of corrections of mitochondrial disorders by pharmacological doses of melatonin. The experimental (30 days) streptozotocin-induced d...

journal_title：Cell biochemistry and function

authors： Cheshchevik VT,Dremza IK,Lapshina EA,Zabrodskaya SV,Kujawa J,Zavodnik IB

更新日期：2011-08-01 00:00:00

abstract：:The effects of Alpinia protocatechuic acid (PCA) on spleen and liver antioxidant system in aged rats have been studied. Alpinia PCA, a phenolic compound, was first isolated from the dried fruits of Alpinia Oxyphylla Miq. in our laboratory. Young and aged rats were injected intraperitoneally with Alpinia PCA at single ...

journal_title：Cell biochemistry and function

authors： Zhang X,Shi GF,Liu XZ,An LJ,Guan S

更新日期：2011-06-01 00:00:00

abstract：:MicroRNA (miRNAs) are short non-coding RNA molecules that downregulate gene expression at post-transcriptional level. miRNAs are post-transcriptional regulators of gene expression important for neuron development and function. This report demonstrated that a putative and chemically synthesized miRNA rno-mir-541 played...

journal_title：Cell biochemistry and function

authors： Zhang J,Zhang J,Liu LH,Zhou Y,Li YP,Shao ZH,Wu YJ,Li MJ,Fan YY,Shi HJ

更新日期：2011-06-01 00:00:00

abstract：:Diabetes induces oxidative stress in aged human and rat, although daily supplementation of vitamins C and E (VCE) can be beneficial to aged diabetic rats by reducing free radical production. The aim of the present study was to evaluate whether dietary VCE supplementation relieves oxidative stress in streptozotocin (ST...

journal_title：Cell biochemistry and function

authors： Özkaya D,Naziroğlu M,Armağan A,Demirel A,Köroglu BK,Çolakoğlu N,Kükner A,Sönmez TT

更新日期：2011-06-01 00:00:00

abstract：:Proteins destined for degradation by the ubiquitin-proteasome system are labelled with a 76-amino acid peptide, ubiquitin, through a series of conjugation steps by the E1, E2 and E3 enzymes respectively. Ubiquitin carboxy-terminal hydrolase 37 (UCH37) belongs to the UCH proteases family that deubiquitinates ubiquitin-...

journal_title：Cell biochemistry and function

authors： Chen Z,Niu X,Li Z,Yu Y,Ye X,Lu S,Chen Z

更新日期：2011-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced inflammatory factors production by the cerebral cortical glial cells in two sides of the murine brain are different. To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1β (IL-1β) and nitric oxide (NO) resp...

journal_title：Cell biochemistry and function

authors： Xin G,Su Y,Gao YL,Zhang H,Wang GF,Li KS

更新日期：2011-01-01 00:00:00

abstract：:Aberrant innate and adaptive immune responsed to allergens and environmental pollutants lead to respiratory allergic disease such as asthma. In this study, we focused on toll-like receptor-4 (TLR4) expressed on airway epithelium to identify house dust mite (HDM)-regulated allergic inflammation via TLR4 signaling pathw...

journal_title：Cell biochemistry and function

authors： Hongjia L,Qingling G,Meiying L,Weixuan W,Lihong Z,Yongsheng G,Yanli L,Jinxiang W,Liang D

更新日期：2010-10-01 00:00:00

abstract：:Hyperglycemia induces overproduction of superoxide and it is related to diabetic complications. In this study, we analyzed the antioxidant enzymatic defense and the lipid peroxidation of rat salivary glands in six different periods of diabetic condition. Ninety-six rats were divided into 12 groups: C7/14/21/28/45/60 (...

journal_title：Cell biochemistry and function

authors： Ibuki FK,Simões A,Nogueira FN

更新日期：2010-08-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and visceral organs. Fibrosis associated with SSc is characterized by an increased synthesis of a wide range of extracellular matrix (ECM). TGF-beta is a pluripotent cytokine in a wide range of cell types. In parti...

journal_title：Cell biochemistry and function

authors： Büyük U,Ates O,Dalyan L,Müsellim B,Ongen G,Topal-Sarikaya A

更新日期：2010-06-01 00:00:00

abstract：:Mitochondrial proton leak can account for almost 20% of oxygen consumption and it is generally accepted that this process contributes to basal metabolism. In order to clarify the role of basal proton leak in testicular mitochondria, we performed a comparative study with kidney and liver mitochondrial fractions. Proton...

journal_title：Cell biochemistry and function

authors： Rodrigues AS,Lacerda B,Moreno AJ,Ramalho-Santos J

更新日期：2010-04-01 00:00:00

abstract：:Cardiac hypertrophy is not only an adaptational state before heart failure but also is an independent risk factor for ischemia, arrhythmia, and sudden death. However, the direct effects of hypercholesterolemia on the myocardium and mechanisms are not completely understood. It has been demonstrated that peroxisome prol...

journal_title：Cell biochemistry and function

authors： Ren L,Li Y,Li Y,Tang R,Hu D,Sheng Z,Liu N

更新日期：2010-01-01 00:00:00